Intenational Literature
Eggshell membrane may support improvement of joint pain and stiffness
(Emy et al., 2016).
This includes:
- Structural protein and glycosaminoglycan composition
- Bioavailability and safety evaluation
- Processing stability and formulation compatibility
Note: This content is for research reference only and does not constitute efficacy claims.
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FAQ
NEM® is a nutritional ingredient extracted from the inner membrane layer of fresh eggs using exclusive patented separation and drying technology, containing standardized hyaluronic acid, chondroitin, and collagen.
NEM® is a patented extract of the inner membrane layer with standardized ingredient quantification and extensive clinical research supporting its efficacy, unlike general powders made by simply grinding eggshells.
Its core indicator components include hyaluronic acid, chondroitin, and collagen, forming a standardized structural matrix.
According to clinical research, improvements in joint pain and stiffness can be observed after 10 days of continuous use.
This means NEM® repurposes byproducts from the food production process into high-quality nutritional ingredients, offering environmental and sustainable value.
NEM® is highly suitable for athletes and outdoor enthusiasts, adults focused on daily nutritional quality, and seniors seeking functional ingredients.
The ingredient has passed GMP, Halal, and Kosher certifications, complying with strict food-grade supply chain management.
Yes, it is derived from the natural inner membrane layer of eggs and is a Clean Label natural nutritional source.
It is recommended to store the products in a cool, dry place and avoid exposure to high temperatures and humidity.
Because it uses patented technology to transform egg byproducts from the food industry into high-value ingredients, earning the Upcycled Certified status in line with modern sustainability trends.
References
Ruff, K. J., Winkler, A., Jackson, R. W., DeVore, D. P., & Ritz, B. W. (2009). Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study. Clinical rheumatology, 28(8), 907-914.
Ruff, K. J., DeVore, D. P., Leu, M. D., & Robinson, M. A. (2009). Eggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clinical Interventions in Aging, 235-240.
Benson, K. F., Ruff, K. J., & Jensen, G. S. (2012). Effects of natural eggshell membrane (NEM) on cytokine production in cultures of peripheral blood mononuclear cells: increased suppression of tumor necrosis factor-α levels after in vitro digestion. Journal of Medicinal Food, 15(4), 360-368.
Ruff, K. J., Endres, J. R., Clewell, A. E., Szabo, J. R., & Schauss, A. G. (2012). Safety evaluation of a natural eggshell membrane-derived product. Food and chemical toxicology, 50(3-4), 604-611. Danesch, U., Seybold, M., Rittinghausen, R., Treibel, W., & Bitterlich, N. (2014). NEM® brand eggshell membrane effective in the treatment of pain associated with knee and hip osteoarthritis: Results from a six center, open label German clinical study. J Arthritis, 3(3), 136.
Danesch, U., Seybold, M., Rittinghausen, R., Treibel, W., & Bitterlich, N. (2014). NEM® brand eggshell membrane effective in the treatment of pain associated with knee and hip osteoarthritis: Results from a six center, open label German clinical study. J Arthritis, 3(3), 136.
Ruff, K. J., & DeVore, D. P. (2014). Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product. Mod Res Inflamm, 3(1), 19-25.
Sim, B. Y., Bak, J. W., Jin, H., Jun, J. A., Choi, H. J., Kwon, C. J., ... & Kim, D. H. (2015). Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats. Journal of Nutrition and Health, 48(4), 310-318.
Ruff, K. J., Durham, P. L., O’Reilly, A., & Long, F. D. (2015). Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy. Journal of inflammation research, 49-57.