Intenational Literature
Apple extract supplementation may support hair growth (increase in hair count from Day 0 to Day 60)
(Tenore,. et al., 2018.)
This includes:
- Appearance-related observational indicators following polyphenol intake
- 60-day clinical follow-up analysis
- Supporting its academic relevance in plant polyphenol and nutritional science research.
Note: This content is for research reference only and does not constitute efficacy claims.
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FAQ
The main ingredient is Annurca apple extract native to Italy, which is rich in Oligomeric Proanthocyanidins (OPC) and various plant polyphenols.
PGI stands for Protected Geographical Indication, which ensures the apples come from the authentic region of origin, guaranteeing consistent quality and reliable sourcing.
It utilizes a traditional "sun-ripening process," allowing the apples to mature in a natural environment, which enhances the levels of polyphenols and OPC.
The human study focused on a 60-day clinical follow-up analysis to observe changes in appearance-related indicators after intake.
It is suitable for office workers who care about their image, women concerned with appearance, men and women with hair thinning concerns, and seniors interested in maintenance.
It can be applied in powders, capsules, tablets, beverages, and skincare products.
AnnurtriComplex® comes from a PGI-certified region and emphasizes a high concentration of polyphenols and OPC, unlike regular apple powder which may only provide flavor or basic nutrition.
Yes, the ingredient has passed international certifications such as FSSC 22000, Halal, and Kosher.
Yes, the product includes compositional analysis and polyphenol data, and a specification sheet can be provided.
It is recommended to pair with Golden Millet Extract (Millet®); the combination provides more comprehensive nutritional support for appearance.
References
Tenore, G. C., Caruso, D., Buonomo, G., D'Avino, M., Santamaria, R., Irace, C., ... & Novellino, E. (2018). Annurca apple nutraceutical formulation enhances keratin expression in a human model of skin and promotes hair growth and tropism in a randomized clinical trial. Journal of medicinal food, 21(1), 90-103.
Badolati, N., Sommella, E., Riccio, G., Salviati, E., Heintz, D., Bottone, S., ... & Novellino, E. (2018). Annurca apple polyphenols ignite keratin production in hair follicles by inhibiting the pentose phosphate pathway and amino acid oxidation. Nutrients, 10(10), 1406.
Riccio, G., Sommella, E., Badolati, N., Salviati, E., Bottone, S., Campiglia, P., ... & Novellino, E. (2018). Annurca apple polyphenols protect murine hair follicles from taxane induced dystrophy and hijacks polyunsaturated fatty acid metabolism toward β-oxidation. Nutrients, 10(11), 1808.
Piccolo, M., Ferraro, M. G., Maione, F., Maisto, M., Stornaiuolo, M., Tenore, G. C., ... & Novellino, E. (2019). Induction of hair keratins expression by an annurca apple-based nutraceutical formulation in human follicular cells. Nutrients, 11(12), 3041.
Badolati, N., Masselli, R., Maisto, M., Di Minno, A., Tenore, G. C., Stornaiuolo, M., & Novellino, E. (2020). Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses. Foods, 9(10), 1461.
Ferraro, M. G., Piccolo, M., Pezzella, A., Guerra, F., Maione, F., Tenore, G. C., ... & Novellino, E. (2021). Promelanogenic effects by an annurca apple-based natural formulation in human primary melanocytes. Clinical, Cosmetic and Investigational Dermatology, 291-301.
Tenore, G. C., Campiglia, P., Ritieni, A., & Novellino, E. (2013). In vitro bioaccessibility, bioavailability and plasma protein interaction of polyphenols from Annurca apple (M. pumila Miller cv Annurca). Food Chemistry, 141(4), 3519-3524.
Tenore, G. C., Caruso, D., Buonomo, G., D'Avino, M., Campiglia, P., Marinelli, L., & Novellino, E. (2017). A healthy balance of plasma cholesterol by a novel annurca apple-based nutraceutical formulation: results of a randomized trial. Journal of medicinal food, 20(3), 288-300.
Sommella, E., Badolati, N., Riccio, G., Salviati, E., Bottone, S., Dentice, M., ... & Novellino, E. (2019). A boost in mitochondrial activity underpins the cholesterol-lowering effect of annurca apple polyphenols on hepatic cells. Nutrients, 11(1), 163.